Toxicological Characterization of the Inorganic and Organic Arsenic Metabolite Thio-DMAV in Cultured Human Lung Cells

Table 1

Cytotoxic effects of the arsenicals in A549 cells after 24 h incubation. Shown are IC70 values for the endpoints cell number and colony forming ability. In case of arsenite, MMA^III, DMA^III, MMA^V, and DMA^V IC70 values were generated from the data originally published in Ebert et al. 2011 [31]; IC70 values represent the respective inhibitory concentrations of the compounds that are required for 30% reduction of cell number or colony forming ability in vitro.

Arsenic species	IC70; (cell number)	IC70; (colony forming ability)
Arsenite	57.2 μM	58.8 μM
MMA^III	5.6 μM	3.8 μM
DMA^III	5.1 μM	3.2 μM
Thio-DMA^V	12.1 μM	7.2 μM
MMA^V	>500 μM	>500 μM
DMA^V	>500 μM	>500 μM