Effect of Glycine on Lead Mobilization, Lead-Induced Oxidative Stress, and Hepatic Toxicity in Rats

Table 2

Lead concentration in the blood (μg/dL), brain, liver, kidney, and bone (μg/g) of rats. Lead was given in drinking water for 5 weeks, after which, the lead was withdrawn, and glycine (100 or 500 mg/kg) treatment was given at a daily oral dose for 5 days, or glycine (1000 mg/kg) treatment was given at a daily oral dose for 28 days.

Treatments	Blood	Brain	Liver	Kidney	Bone
Glycine (100 mg/kg)	40.5 ± 2.3	1.25 ± 0.24	2.2 ± 0.20	10.1 ± 1.3	499.9 ± 16.3
Glycine (500 mg/kg)	39.1 ± 2.1	1.41 ± 0.24	1.9 ± 0.30	9.1 ± 1.4	446.9 ± 42.8
Glycine (1000 mg/kg)	22.5 ± 1.9	0.91 ± 0.18	0.80 ± 0.40	5.9 ± 1.7	306.9±35.5^a

^a𝑃<0.05 compared with its positive lead control.