Oxidative Toxicity in Neurodegenerative Diseases: Role of Mitochondrial Dysfunction and Therapeutic Strategies

Figure 1

Environmental toxins cause the production of ROS by inhibiting complex I of the electron transport chain (ETC) and decrease the production of ATP. This ROS contributes to a loss in the mitochondrial membrane potential and well as disruption of mitochondrial permeability transition pores and voltage-dependant anion channels contributing to apoptosis. ROS also moves to the cytosol where it oxidizes proteins, DNA, and lipids.