Research Article
Cardiorenal Effects of Newer NSAIDs (Celecoxib) versus Classic NSAIDs (Ibuprofen) in Patients with Arthritis
Table 1
Baseline characteristics and exposure to treatment.
| | Celecoxib 400 mg b.i.d. (N = 396) | Ibuprofen 800 mg t.d.s. (N = 396) |
| Exposure to treatment median (days) | 182 | 176 |
| Age | | | Mean (years) | 55.2 | 54.9 | 60–70 years (%) | 26.6 | 25.5 | ≥70 years (%) | 5.2 | 3.9 |
| Female | 68.5 | 70.8 |
| History (%) | | | Hypertension | 39.0 | 38.1 | Diabetes | 8.8 | 8.1 |
| Creatinine | | | Serum level (mg/dL) | 0.79 | 0.77 | Clearance (mL/min.)* | 112.2 | 116.4 |
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b.i.d. twice a day; t.d.s. three times a day.
*estimated by Cockroft-Gault formula.
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