Cardiorenal Effects of Newer NSAIDs (Celecoxib) versus Classic NSAIDs (Ibuprofen) in Patients with Arthritis

Table 2

Blood pressure effects of celecoxib versus ibuprofen.

Event	Celecoxib; 400 mg b.i.d.; (N = 396)	Ibuprofen; 800 mg t.d.s.; (N = 396)
Any hypertension adverse event (% of patients)^§	2.7	4.2*
New-onset hypertension (% of patients)	2.0	3.1*
Aggravated hypertension (% of patients)	0.8	1.2
Withdrawal for hypertension related adverse effects (% of patients)^§	0.3	0.3
Mean change in blood pressure (mmHg)
Systolic	−0.6	>20*
Diastolic	−0.7	3.2
Increases in blood pressure (% of patients)^#
Systolic >20 mmHg from baseline and absolute value > 140 mmHg	5.0	7.0*
Diastolic >15 mmHg from baseline and absolute value > 90 mmHg	1.9	2.2

b.i.d. twice a day; t.d.s. three times a day.
^§New-onset or aggravated.
^#observed at final clinic visit.
* P <.05 versus celecoxib by Fisher exact test.