Research Article
Ethylene Oxide: Acute Four-Hour and One-Hour Inhalation Toxicity Testing in Rats
Table 2
Clinical observations, mortality rates, and day of death for female rats following 4-hour exposure to EO.
| Exposure group (ppm) | Clinical signs | Mortality | Number found dead Observation day | During exposure or same day following exposure | During five days of postexposure period | Number dead/total | 0a | 1 | 2 | 3 |
| 1850 | Periocular/perinasal wetness, gasping, audible respiration, hypoactivity | Periocular/perinasal encrustation, unkempt fur, audible respiration, decreased respiration rate, hypoactivity | 5/5 | 0b | 3 | 2 | 0 |
| 1637 | Periocular/perinasal/perioral wetness, gasping, audible respiration, hypoactivity, absence tail/toe pinch reflex | Perinasal/perioral encrustation, unkempt fur, audible respiration, decreased respiration rate, hypoactivity, tremors | 4/5 | 0 | 3 | 0 | 1 |
| 1443 | Periocular/perinasal/perioral wetness, gasping, audible respiration, hypoactivity, tremors | Perinasal encrustation | 1/5 | 0 | 1 | 0 | 0 |
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aDay 0 is exposure day. Days 1, 2, and 3 are days following exposure day.
bNumber of animals found dead on a particular day.
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