Potassium Channels Blockers from the Venom of Androctonus mauretanicus mauretanicus
Figure 1
MALDI-TOF mass spectra of pool venom manually extracted from Androctonus mauretanicus mauretanicus. K+ channel blockers and voltage-gated Na+ channels modulators are indicated. P01 and P05, blockers of SKCa channels; AmmTX3, blockers of Kv4 and hERG channels; KTX, Kv1.1, and Kv1.3 blockers. Amm III and Amm V are major lethal α-toxins; β-toxins specific for insects are also mentioned. The 3D structure of KTX (left) and of the α-toxin of reference AaH II from Androctonus australis (right) are shown [13, 24, 25]. The Cys-Stabilized-Helix (CSH) motif is shown in inset [8].
