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Journal of Toxicology
Volume 2012 (2012), Article ID 131854, 8 pages
http://dx.doi.org/10.1155/2012/131854
Research Article

Reconstructing Organophosphorus Pesticide Doses Using the Reversed Dosimetry Approach in a Simple Physiologically-Based Pharmacokinetic Model

1Department of Environmental Health, Harvard School of Public Health, 401 Park Drive, Boston, MA 02215, USA
2Atlanta Clinical and Translational Science Institute, School of Medicine, Emory University, 1440 Clifton Road, Atlanta, GA 30322, USA

Received 6 September 2011; Revised 21 October 2011; Accepted 24 October 2011

Academic Editor: Marina V. Evans

Copyright © 2012 Chensheng Lu and Leo Andres. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We illustrated the development of a simple pharmacokinetic (SPK) model aiming to estimate the absorbed chlorpyrifos doses using urinary biomarker data, 3,5,6-trichlorpyridinol as the model input. The effectiveness of the SPK model in the pesticide risk assessment was evaluated by comparing dose estimates using different urinary composite data. The dose estimates resulting from the first morning voids appeared to be lower than but not significantly different to those using before bedtime, lunch or dinner voids. We found similar trend for dose estimates using three different urinary composite data. However, the dose estimates using the SPK model for individual children were significantly higher than those from the conventional physiologically based pharmacokinetic (PBPK) modeling using aggregate environmental measurements of chlorpyrifos as the model inputs. The use of urinary data in the SPK model intuitively provided a plausible alternative to the conventional PBPK model in reconstructing the absorbed chlorpyrifos dose.