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Journal of Toxicology
Volume 2012 (2012), Article ID 131854, 8 pages
Reconstructing Organophosphorus Pesticide Doses Using the Reversed Dosimetry Approach in a Simple Physiologically-Based Pharmacokinetic Model
1Department of Environmental Health, Harvard School of Public Health, 401 Park Drive, Boston, MA 02215, USA
2Atlanta Clinical and Translational Science Institute, School of Medicine, Emory University, 1440 Clifton Road, Atlanta, GA 30322, USA
Received 6 September 2011; Revised 21 October 2011; Accepted 24 October 2011
Academic Editor: Marina V. Evans
Copyright © 2012 Chensheng Lu and Leo Andres. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. L. Rigas, M. S. Okino, and J. J. Quackenboss, “Use of a pharmacokinetic model to assess chlorpyrifos exposure and dose in children, based on urinary biomarker measurements,” Toxicological Sciences, vol. 61, no. 2, pp. 374–381, 2001.
- C. Timchalk, R. J. Nolan, A. L. Mendrala, D. A. Dittenber, K. A. Brzak, and J. L. Mattsson, “A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans,” Toxicological Sciences, vol. 66, no. 1, pp. 34–53, 2002.
- X. Zhang, A. M. Tsang, M. S. Okino et al., “A physiologically based pharmacokinetic/pharmacodynamic model for carbofuran in sprague-dawley rats using the exposure-related dose estimating model,” Toxicological Sciences, vol. 100, no. 2, pp. 345–359, 2007.
- C. A. Ellison, J. N. Smith, P. J. Lein, and J. R. Olson, “Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos,” Toxicology, vol. 287, no. 1–3, pp. 137–144, 2011.
- J. N. Blancato, “Pharmacokinetics, chemical interactions, and toxicological risk assessment in perspective,” Environmental Health Perspectives, vol. 102, supplement 9, pp. 133–137, 1994.
- H. J. Clewell, P. R. Gentry, J. M. Gearhart, B. C. Allen, and M. E. Andersen, “Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model,” Science of the Total Environment, vol. 274, no. 1–3, pp. 37–66, 2001.
- J. B. Knaak, C. C. Dary, M. S. Okino et al., “Parameters for carbamate pesticide QSAR and PBPK/PD models for human risk assessment,” Reviews of Environmental Contamination and Toxicology, vol. 193, pp. 53–212, 2008.
- A. Campbell, “Development of PBPK model of molinate and molinate sulfoxide in rats and humans,” Regulatory Toxicology and Pharmacology, vol. 53, no. 3, pp. 195–204, 2009.
- P. L. Mosquin, A. C. Licata, B. Liu, S. C. Sumner, and M. S. Okino, “Reconstructing exposures from small samples using physiologically based pharmacokinetic models and multiple biomarkers,” Journal of Exposure Science & Environmental Epidemiology, vol. 19, no. 3, pp. 284–297, 2009.
- S. J. Godin, M. J. DeVito, M. F. Hughes et al., “Physiologically based pharmacokinetic modeling of deltamethrin: development of a rat and human diffusion-limited model,” Toxicological Sciences, vol. 115, no. 2, pp. 330–343, 2010.
- C. Lu, C. M. Holbrook, and L. M. Andres, “The implications of using a physiologically based pharmacokinetic (PBPK) model for pesticide risk assessment,” Environmental Health Perspectives, vol. 118, no. 1, pp. 125–130, 2010.
- R. Tornero-Velez, A. Mirfazaelian, K. B. Kim et al., “Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model,” Toxicology and Applied Pharmacology, vol. 244, no. 2, pp. 208–217, 2010.
- P. G. Georgopoulos, A. F. Sasso, S. S. Isukapalli et al., “Reconstructing population exposures to environmental chemicals from biomarkers: challenges and opportunities,” Journal of Exposure Science & Environmental Epidemiology, vol. 19, no. 2, pp. 149–171, 2009.
- Y. M. Tan, K. Liao, R. Conolly, B. Blount, A. Mason, and H. Clewell, “Use of a physiologically based pharmacokinetic model to identify exposures consistent with human biomonitoring data for chloroform,” Journal of Toxicology and Environmental Health A, vol. 69, no. 18, pp. 1727–1756, 2006.
- H. J. Clewell, Y. M. Tan, J. L. Campbell, and M. E. Andersen, “Quantitative interpretation of human biomonitoring data,” Toxicology and Applied Pharmacology, vol. 231, no. 1, pp. 122–133, 2008.
- C. Timchalk, T. S. Poet, M. N. Hinman, A. L. Busby, and A. A. Kousba, “Pharmacokinetic and pharmacodynamic interaction for a binary mixture of chlorpyrifos and diazinon in the rat,” Toxicology and Applied Pharmacology, vol. 205, no. 1, pp. 31–42, 2005.
- J. N. Blancato, F. W. Power, R. N. Brown, and C. C. Dary, “) Exposure Related Dose Estimating Model (ERDEM) a Physiologically-Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) model for assessing human exposure and risk,” Tech. Rep. EPA/600/R-06/061, U.S. Environmental Protection Agency, Washington, DC, USA, 2006, (NTIS PB2006-114712).
- C. Lu, G. Kedan, J. Fisker-Andersen, J. C. Kissel, and R. A. Fenske, “Multipathway organophosphorus pesticide exposures of preschool children living in agricultural and nonagricultural communities,” Environmental Research, vol. 96, no. 3, pp. 283–289, 2004.
- R. A. Fenske, C. Lu, G. Kedan, J. Fisker-Andersen, and C. Curl, “Assessment of organophosphorous pesticide exposures in the diets of preschool children in Washington State,” Journal of Exposure Analysis and Environmental Epidemiology, vol. 12, no. 1, pp. 21–28, 2002.
- J. C. Kissel, C. L. Curl, G. Kedan et al., “Comparison of organophosphorus pesticide metabolite levels in single and multiple daily urine samples collected from preschool children in Washington State,” Journal of Exposure Analysis and Environmental Epidemiology, vol. 15, no. 2, pp. 164–171, 2005.
- M. L. Voorhess, “Urinary catecholamine excretion by healthy children. I. Daily excretion of dopamine, norepinephrine, epinephrine, and 3-methoxy-4-hydroxymandelic acid,” Pediatrics, vol. 39, no. 2, pp. 252–257, 1967.
- United States Environmental Protection Agency (USEPA). Exposure Factor Handbook, 1997, http://rais.ornl.gov/documents/EFH_Final_1997_EPA600P95002Fa.pdf.
- P. Griffin, H. Mason, K. Heywood, and J. Cocker, “Oral and dermal absorption of chlorpyrifos: a human volunteer study,” Occupational and Environmental Medicine, vol. 56, no. 1, pp. 10–13, 1999.
- M. K. Morgan, L. S. Sheldon, C. W. Croghan et al., “Exposures of preschool children to chlorpyrifos and its degradation product 3,5,6-trichloro-2-pyridinol in their everyday environments,” Journal of Exposure Analysis and Environmental Epidemiology, vol. 15, no. 4, pp. 297–309, 2005.
- C. Lu, R. Bravo, L. M. Caltabiano, R. M. Irish, G. Weerasekera, and D. B. Barr, “The presence of dialkylphosphates in fresh fruit juices: implication for organophosphorus pesticide exposure and risk assessments,” Journal of Toxicology and Environmental Health A, vol. 68, no. 3, pp. 209–227, 2005.