Table 2: The dose estimates ( 𝜇 g/kg/day) for chlorpyrifos using PBPK, SPK I, SPK II and SPK III model simulations.

Subject ID1SeasonBody wt. (kg)PBPKSPK I2SPK II3SPK III4

R1Summer15.50.0040.5460.2731.140
R2Summer21.40.0030.2810.2460.380
R3Summer14.50.0040.0430.0220.014
R4Summer16.80.0030.8311.4390.987
R5Summer13.40.0040.3380.2130.158
R6Summer19.60.003n.a. 50.8400.520
S1Summer17.30.003000
S2Summer18.200.2240.1120.488
S3Summer150n.a. 53.3572.497
S4Summer15.501.8811.4501.282
S5Summer16.80.004n.a. 5n.a. 50.326
S6Summer22.70.4400.8080.8200.672
S7Summer14.50n.a. 5n.a. 51.056
R1Fall15.50.0041.8812.2741.973
R2Fall21.40.0030.0510.2040.229
R3Fall14.50.0120.3470.9800.944
R4Fall16.80.0030.3660.5410.603
R5Fall13.40.0180.0820.4830.368
R6Fall19.60.0050.4760.4760.250
S1Fall17.32.3029.1255.4963.647
S2Fall18.20.0030.1720.9491.110
S3Fall150.0041.0601.0601.219
S4Fall15.500.9561.2601.017
S5Fall16.801.0281.1840.922
S6Fall22.70.0010.0410.9690.934
S7Fall14.50.006n.a. 5n.a. 51.513

1 “R” for children living in agricultural community and “S” for children living in urban/suburban community.
2 Significantly different to PBPK dose estimates (paired t-test, 𝑃 < 0 . 0 0 1 ).
3 Significantly different to PBPK dose estimates (paired t-test, 𝑃 = 0 . 0 2 ).
4 Significantly different to PBPK dose estimates (paired t-test, 𝑃 < 0 . 0 0 1 ).
5 Missing data due to missing spot urine samples.