Kinetic and Reaction Pathway Analysis in the Application of Botulinum Toxin A for Wound Healing

Figure 3

Time course of recurrence of CAF symptoms in some patients (22 of 53) in a 42-month follow-up study [55]. Initially (𝑡=0, i.e., 6 months after injection), all 53 patients were symptom-free for 6 months after injection of 10–20 U BOTOX. The fitted values from (2) (see text) are 𝑦₀=29.2, 𝑎=24.4, and 𝑘_decay=0.85 years⁻¹. The 𝑦-axis represents the number of symptom-free patients. Dashed line is fitted data; solid lines are 95% C.I.