Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease

Figure 2

Ethanol ingestion results in increased protein-SSG. (a) Immunohistochemical staining with antibodies directed against protein-SSG reveals a marked increase in the zone 3 staining in the week 6 ethanol-fed mice. (b) pan-GST activity and (c) GRx activity significantly elevated at week 6. Magnification: 400x. Scale bar represents approximately 50 μm. PT: portal triad: CV: central vein (𝑛=6, **𝑃<0.01, ***𝑃<0.001).

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