Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease

Table 2

Significant signs of alcohol-mediated liver injury are achieved following 6 weeks of ethanol ingestion. Blood ethanol concentration (BEC) is reported as mg/dL; ethanol ingestion results in a significant increase in liver-body weight ratio as early as 3 weeks; plasma ALT activity is significantly elevated after week 6. Values represent the average ± standard error of the mean (𝑛=12, ^∗𝑃<0.05, ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001).

Parameter	Week 1		Week 3		Week 6
	Control	Ethanol	Control	Ethanol	Control	Ethanol
Food	15.031 ± 0.263	16.510 ± 0.302^***	15.151 ± 0.181	16.389 ± 0.183^***	16.994 ± 0.205	17.778 ± 0.326^**
Consumption/day
(mL/Day)
BEC (mg/dL)	N/A	20.848 ± 0.367	N/A	32.577 ± 6.293	N/A	245.383 ± 33.747
Body weight (g)	25.667 ± 0.607	25.000 ± 0.663	26.900 ± 0.688	26.392 ± 0.601	31.017 ± 0.752	25.783 ± 0.647^***
Liver weight (g)	1.102 ± 0.036	1.113 ± 0.031	1.086 ± 0.035	1.190 ± 0.034	1.148 ± 0.038	1.123 ± 0.036
Liver/body weight	0.043 ± 0.001	0.045 ± 0.000	0.040 ± 0.000	0.045 ± 0.001^**	0.038 ± 0.001	0.044 ± 0.001^***
Serum ALT activity (U/L)	15.698 ± 1.076	14.744 ± 0.803	11.332 ± 1.175	10.090 ± 0.808	18.411 ± 4.612	42.985 ± 4.523^**