Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans

Figure 4

Comparison of PBPK model simulation with experimental data of venous blood concentration following inhalation exposure to (a) 100 ppm, 6 h dichloromethane [77]; (b) 33 ppm, 7 h ethylbenzene [67]; (c) 80 ppm, 6 h styrene [78]; (d) 17 ppm, 7 h toluene [67]; (e) 33 ppm, 7 h m-xylene [67]. Bold lines: predicted LMCI and UMCI for 𝐶𝐿_int.

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