Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans

<table>Comparison of the predicted log <svg height="14.4375" id="M235" style="vertical-align:-3.22282pt" version="1.1" viewbox="0 0 38.150002 14.4375" width="38.150002" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝐶</tspan>
<tspan style="font-size: 12.50px; " x="8.389513" y="0">𝐿</tspan>
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</svg> (LMCI and UMCI) with the experimental data on 11 VOCs. The bars represent the QPPR predictions and the symbols the experimental values. A: 1,1,1-trichloroethane; B: 1,2,4-trimethylbenzene; C: 1,2-dichloroethylene (<i>trans</i>-); D: bromoform; E: dibromochloromethane; F: ethylene; G: furan; H: halothane; I: <i>o</i>-xylene; J: propylene; K: tetrachloroethylene.</table>

Journal of Toxicology

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Figure 5

Figure 5: Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans 

Figure 5 | Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans 