Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans
Figure 7
Comparison of PBPK model simulations (bold lines: predicted LMCI and UMCI for ) with experimental data of venous blood concentration following inhalation exposure to (a) 8 ppm, 4 h 1,2,4-trimethylbenzene [59] and (b) 175 ppm, 3.5 h 1,1,1-trichloro ethane [85].
