Table 3: Area under the curve for four metabolic scenarios for the VOCs used in the QPPR development.

Chemicals24 h Area under the curve (mg/L-h)
Metabolic scenarioa
𝐸 m i n 𝐸 m a x LMCIUMCI

Benzene0.4370.1250.1550.138
Bromochloromethane0.9130.2290.3050.257
Bromodichloromethane2.3800.3560.5230.422
Carbon tetrachloride0.340.1530.2240.186
Chloroethane0.1560.0690.0840.076
Chloroform0.5990.1850.2570.211
Dibromomethane1.6590.3360.4660.384
Dichloroethane (1,1-)0.3910.1380.1810.158
Dichloroethane (1,2-)1.1420.2050.3050.241
Dichloroethylene (1,1-) 6 . 9 8 × 1 0 2 4 . 2 2 × 1 0 2 4 . 7 6 × 1 0 2 4 . 4 7 × 1 0 2
Dichloroethylene (cis-1,2)0.7020.1740.2140.188
Dichloromethane0.650.1570.2060.174
Ethylbenzene1.2470.2160.320.246
Hexachloroethane3.0710.4941.7740.738
Hexane (n-)0.150.0730.1290.084
Isoprene 4 . 5 9 × 1 0 2 2 . 8 1 × 1 0 2 0.084 2 . 9 5 × 1 0 2
Methyl chloride0.1190.0540.0640.057
Pentachloroethane2.5840.4180.9290.595
Styrene1.4970.2220.3220.246
Tetrachloroethane (1,1,1,2-)1.9110.3370.7390.457
Tetrachloroethane (1,1,2,2-)3.3370.3840.7170.495
Toluene0.740.1680.2230.188
Trichloroethane (1,1,2-)1.8760.2840.4740.355
Trichloroethylene0.7210.2090.2670.227
Vinyl chloride 6 . 6 8 × 1 0 2 3 . 7 9 × 1 0 2 4 . 2 5 × 1 0 2 3 . 9 8 × 1 0 2
Xylene (m-)1.1170.2090.3080.236

a: 𝐸 m i n : no metabolism; 𝐸 m a x : maximum hepatic extraction; LMCI and UMCI: lower and upper bound of the 95% mean confidence interval, respectively.