Phospholipogenic Pharmaceuticals Are Associated with a Higher Incidence of Histological Findings than Nonphospholipogenic Pharmaceuticals in Preclinical Toxicology Studies

Figure 1

Percentage of study reports by species for both phospholipogenic and nonphospholipogenic datasets. Where there were multiple study reports for a compound tested in the same species, reports were counted as a single “report” to minimize weighting bias. There were 29% (of the total) (or 1.6-fold) more rat study “reports” available in the phospholipogenic dataset than the negatives dataset, whereas there were 28% (of the total) (or 2.8-fold) more dog study “reports” available in the negative dataset than the phospholipogenic dataset. Phospholipidosis potential (descriptors and pathologists interpretation) identified in study reports for all compounds was also confirmed in silico or in vitro.