A Lipocalin-Derived Peptide Modulating Fibroblasts and Extracellular Matrix Proteins

Figure 3

Peptide treatment increases collagen in the mice dermis. (a) Mean values of groups treated with a single dose (0.2 mL, 1.15 μM pm2b, i.d.) or repeated doses compared with controls (𝑛 = 4–6). (b) Matched observations of pm2b-treated and saline-treated sites (1 × 1 cm) in the same animals in successive intervals after treatment. (c) Picrosirius-red-stained sections (originally 340x). Data are representative images and expressed as mean ± SEM. ^∗∗𝑃<0.01, ^∗𝑃<0.05 versus control.

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