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Journal of Toxicology
Volume 2012 (2012), Article ID 359471, 11 pages
Review Article

Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment: Three Case Studies

1Federal Institute for Risk Assessment, Max Dohrn Strasse 8-10, 10589 Berlin, Germany
2Institute for Clinical Pharmacology and Toxicology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany

Received 10 October 2011; Revised 28 January 2012; Accepted 16 February 2012

Academic Editor: Jane C. Caldwell

Copyright © 2012 Hans Mielke and Ursula Gundert-Remy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [8 citations]

The following is the list of published articles that have cited the current article.

  • Ying Jiang, Juan Liu, Yuanyuan Li, Huailong Chang, Gengqi Li, Bing Xu, Xi Chen, Weiyong Li, Wei Xia, and Shunqing Xu, “Prenatal exposure to bisphenol A at the reference dose impairs mitochondria in the heart of neonatal rats,” Journal of Applied Toxicology, vol. 34, no. 9, pp. 1012–1022, 2013. View at Publisher · View at Google Scholar
  • Falko Partosch, Hans Mielke, and Ursula Gundert-Remy, “Functional UDP-glucuronyltransferase 2B15 polymorphism and bisphenol A concentrations in blood: Results from physiologically based kinetic modelling,” Archives of Toxicology, vol. 87, no. 7, pp. 1257–1264, 2013. View at Publisher · View at Google Scholar
  • Laura N. Vandenberg, Patricia A. Hunt, John Peterson Myers, and Frederick S. Vom Saal, “Human exposures to bisphenol A: Mismatches between data and assumptions,” Reviews on Environmental Health, vol. 28, no. 1, pp. 37–58, 2013. View at Publisher · View at Google Scholar
  • Ursula Gundert-Remy, Hans Mielke, and Ulrike Bernauer, “Commentary: Dermal penetration of bisphenol A-Consequences for risk assessment,” Toxicology Letters, vol. 217, no. 2, pp. 159–161, 2013. View at Publisher · View at Google Scholar
  • Jos G. Bessems, George Loizou, Kannan Krishnan, Harvey J. Clewell, Camilla Bernasconi, Frederic Bois, Sandra Coecke, Eva-Maria Collnot, Walter Diembeck, Lucian Romeo Farcal, Liesbeth Geraets, Ursula Gundert-Remy, Nynke Kramer, Gabriele Küsters, Sofia B. Leite, Olavi R. Pelkonen, Klaus Schröder, Emanuela Testai, Iwona Wilk-Zasadna, and José-Manuel Zaldívar-Comenges, “PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment,” Regulatory Toxicology and Pharmacology, vol. 68, no. 1, pp. 119–139, 2014. View at Publisher · View at Google Scholar
  • Bridget F Healy, Karin R English, Paul Jagals, and Peter D Sly, “Bisphenol A exposure pathways in early childhood: Reviewing the need for improved risk assessment models,” Journal of Exposure Science and Environmental Epidemiology, 2015. View at Publisher · View at Google Scholar
  • U. Gundert-Remy, H. Barth, A. Bürkle, G. H. Degen, and R. Landsiedel, “Toxicology: a discipline in need of academic anchoring—the point of view of the German Society of Toxicology,” Archives of Toxicology, 2015. View at Publisher · View at Google Scholar
  • Tewes Tralau, Michael Oelgeschläger, Rainer Gürtler, Gerhard Heinemeyer, Matthias Herzler, Thomas Höfer, Heike Itter, Thomas Kuhl, Nikola Lange, Nicole Lorenz, Christine Müller-Graf, Ulrike Pabel, Ralph Pirow, Vera Ritz, Helmut Schafft, Heiko Schneider, Thomas Schulz, David Schumacher, Sebastian Zellmer, Gaby Fleur-Böl, Matthias Greiner, Monika Lahrssen-Wiederholt, Alfonso Lampen, Andreas Luch, Gilbert Schönfelder, Roland Solecki, Reiner Wittkowski, and Andreas Hensel, “Regulatory toxicology in the twenty-first century: challenges, perspectives and possible solutions,” Archives of Toxicology, 2015. View at Publisher · View at Google Scholar