Thimerosal-Derived Ethylmercury Is a Mitochondrial Toxin in Human Astrocytes: Possible Role of Fenton Chemistry in the Oxidation and Breakage of mtDNA

<table>Colocalization of carbonyls and mtDNA damage normal human astrocytes. Thimerosal-induced oxidative damage occurs at mitochondrial matrix level. Nuclei (blue), carbonyls (red), and 3′OH DNA ends (green) in (a) and <i>Fpg</i>-labile DNA bases/apurinic and apyrimidinic sites (green) in (b). (c) (insert): A cell that has entered the final stages of apoptosis with large numbers of 3′OH DNA ends derived from nuclear DNA. </table>

Journal of Toxicology

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Figure 4: Thimerosal-Derived Ethylmercury Is a Mitochondrial Toxin in Human Astrocytes: Possible Role of Fenton Chemistry in the Oxidation and Breakage of mtDNA 

Figure 4 | Thimerosal-Derived Ethylmercury Is a Mitochondrial Toxin in Human Astrocytes: Possible Role of Fenton Chemistry in the Oxidation and Breakage of mtDNA 