Subchronic Hepatotoxicity Evaluation of 2,3,4,6-Tetrachlorophenol in Sprague Dawley Rats

Figure 2

Liver (200 mg/kg/day TCP following 13 weeks exposure) characterized by marked hepatocellular hypertrophy and hepatocellular vacuolation bridging from one centrilobular area (C) to the next. Both the portal (P) and centrilobular veins (C) are compressed. Single cell necrosis is indicated by arrows. H & E, 10x.