Research Article

Subchronic Hepatotoxicity Evaluation of 2,3,4,6-Tetrachlorophenol in Sprague Dawley Rats

Table 2

Blood TCP concentration (μg/mL) in male SD rats following 5 days, 2 weeks, 4 weeks, and 13 weeks of daily exposure of TCP by oral gavage.

Time pointTCP dose (mg/kg/day)
0102550100

5 days 0 . 0 ± 0 . 0 1 0 . 8 ± 0 . 1 2 . 8 ± 0 . 9 6 . 6 ± 2 . 7 9 . 5 ± 2 . 6 1 9 . 6 ± 5 . 7
2 weeks 0 . 0 ± 0 . 0 1 . 2 ± 0 . 4 6 . 7 ± 1 . 6 1 1 . 3 ± 5 . 4 2 1 4 . 0 ± 1 . 7 1 6 . 7 ± 2 . 0
4 weeks 0 . 0 ± 0 . 0 0 . 8 ± 0 . 5 2 . 3 ± 1 . 0 5 . 6 ± 2 . 3 8 . 0 ± 2 . 7 1 5 . 4 ± 4 . 4
13 weeks 0 . 0 ± 0 . 0 1 . 3 ± 0 . 7 2 . 2 ± 0 . 7 5 . 3 ± 1 . 7 8 . 7 ± 2 . 9 8 . 5 ± 2 . 0

1Values are mean ± standard deviation ( 𝑛 = 5 ).
2 𝑛 = 6 .