Table 3: Select serum chemistry concentrations (IU/L) of male SD rats following 5 days, 2 weeks, 4 weeks, and 13 weeks of daily exposure of TCP by oral gavage.

Time pointAnalyteTCP dose (mg/kg/day)
0102550100200

5 DaysALP1 6 2 1 ± 2 0 4 4 5 1 5 ± 2 0 5 6 8 1 ± 2 1 2 5 8 5 ± 1 6 3 6 1 0 ± 1 0 6 7 6 1 ± 1 7 8
ALT2 4 0 ± 8 3 5 ± 1 0 3 8 ± 1 1 4 1 ± 1 2 4 1 ± 2 0 5 0 ± 1 5
AST3 1 1 8 ± 1 4 1 0 9 ± 3 6 1 1 6 ± 3 6 1 1 8 ± 2 5 1 2 9 ± 3 3 1 2 6 ± 3 1

2 WeeksALP 5 1 1 ± 2 1 9 5 3 7 ± 1 4 0 5 5 5 ± 1 4 6 5 6 4 ± 2 0 9 5 6 6 ± 1 8 7 6 5 3 ± 1 2 0
ALT 4 0 ± 1 3 4 0 ± 1 1 5 2 ± 5 1 3 1 ± 1 1 4 2 ± 1 3 6 8 ± 2 1
AST 1 2 6 ± 5 6 1 2 7 ± 4 2 1 3 7 ± 8 3 1 1 6 ± 5 1 1 3 2 ± 3 6 1 4 4 ± 1 8

4 WeeksALP 4 0 7 ± 1 2 8 5 0 0 ± 1 4 0 4 6 3 ± 1 1 8 4 8 9 ± 9 8 5 3 0 ± 1 8 0 5 2 3 ± 1 2 3
ALT 4 3 ± 9 3 9 ± 8 3 9 ± 9 3 8 ± 8 4 7 ± 1 0 5 7 ± 1 0
AST 1 2 2 ± 2 3 1 3 4 ± 2 0 1 2 9 ± 2 5 1 1 9 ± 1 4 1 2 3 ± 1 1 1 2 4 ± 1 3

13 WeeksALP 3 0 4 ± 8 3 2 9 5 ± 1 0 2 3 9 6 ± 1 5 3 3 5 7 ± 1 1 5 4 2 5 ± 1 1 5 5 8 5 ± 1 2 7
ALT 3 8 ± 1 4 4 2 ± 9 5 7 ± 5 2 6 1 ± 3 9 6 3 ± 2 9 1 2 0 ± 4 7
AST 1 2 5 ± 2 4 1 3 0 ± 1 7 1 3 7 ± 2 1 1 5 2 ± 4 5 1 5 1 ± 2 2 2 4 4 ± 5 9

1ALP: alkaline phosphatase.
2ALT: alanine aminotransferase.
3AST: aspartate aminotransferase.
4mean ± standard deviation for 𝑛 = 1 0 except for the following groups: 𝑛 = 9 (25 and 50 mg/kg/day, 13 weeks); 𝑛 = 1 1 (0 mg/kg/day, 5 days, 2 weeks, and 4 weeks); 𝑛 = 1 2 (0 mg/kg/day, 13 weeks).
* 𝑃 < 0 . 0 5 compared to control.
** 𝑃 < 0 . 0 1 compared to control.