Caspase-10 Is the Key Initiator Caspase Involved in Tributyltin-Mediated Apoptosis in Human Immune Cells

Figure 7

Proposed scheme of TBT-induced apoptosis in Jurkat cells. TBT activates caspase-10 upstream of mitochondria which leads to BID cleavage, and activation of the mitochondria. Downstream caspases were then cleaved and the caspase-cascade is provoked. Caspase-8 deficiency cannot prevent apoptosis, but inhibition of caspase-10 (AEVD) or inhibition of the two important caspases downstream of the mitochondria, caspase-9 and caspase-3 (LEHD and DEVD), totally suppress cell death.