Modeling the Human Kinetic Adjustment Factor for Inhaled Volatile Organic Chemicals: Whole Population Approach versus Distinct Subpopulation Approach
Table 6
Percentage of individuals in the diverse Canadian subpopulations that are covered by the HKAF and the default factor for various dose metrics and chemicals.
Subpopulation Variability descriptor
Dose metrics
Benzene
1,4-Dioxane
CAss (%)
RAM (%)
CAss (%)
RAM (%)
Adults
“whole population”(a) HKAF95th
96
96
95
97
“whole population”(a) HKAF99th
99
>99
>99
>99
Default 3.16 factor
100
100
>99
100
Neonates
“whole population”(a) HKAF95th
57
100
27
100
“whole population”(a) HKAF99th
73
100
48
100
Default 3.16 factor
100
100
60
100
Infants
“whole population”(a) HKAF95th
89
97
76
97
“whole population”(a) HKAF99th
97
>99
92
>99
Default 3.16 factor
100
100
97
100
Toddlers
“whole population”(a) HKAF95th
93
97
92
96
“whole population”(a) HKAF99th
99
>99
99
99
Default 3.16 factor
100
100
>99
100
Children and adolescents
“whole population”(a) HKAF95th
96
96
98
95
“whole population”(a) HKAF99th
>99
>99
>99
>99
Default 3.16 factor
100
100
100
100
Elderly
“whole population”(a) HKAF95th
95
96
95
96
“whole population”(a) HKAF99th
>99
99
99
>99
Default 3.16 factor
100
100
>99
100
Pregnant Women
“whole population”(a) HKAF95th
78
63
86
66
“whole population”(a) HKAF99th
92
85
96
86
Default 3.16 factor
100
100
98
100
Canadian population
Greatest(b) “distinct subpopulation” HKAF95th
>99
>99
>99
>99
Greatest(b) “distinct subpopulation” HKAF99th
>99
>99
>99
>99
Default 3.16 factor
100
100
>99
100
Based on the median value in the whole Canadian population. Based on the median value in adults in Table 5. CAss: blood concentration of parent compound (μg/L); RAM: rate of metabolism (μg/h-L of liver).
