Safety Assessment of Zigbir®: A Polyherbal Formulation in Sprague-Dawley Rats

Table 7

Absolute organ weights (g; mean ± SD) in female rats after 90 days subchronic oral administration of Zigbir®.

Organ	Control	250 mg/kg	500 mg/kg	1000 mg/kg	Control recovery	1000 mg/kg recovery
Terminal body weight	232.66 ± 11.33	228.66 ± 14.67	216.17 ± 10.90	204.97 ± 6.75	268.78 ± 20.25	255.00 ± 12.83
Brain	1.843 ± 0.075	1.909 ± 0.079	1.805 ± 0.076	1.719 ± 0.075	1.837 ± 0.060	1.824 ± 0.054
Liver	6.940 ± 1.060	8.049 ± 0.478	7.062 ± 0.898	6.111 ± 0.531	8.379 ± 1.137	7.635 ± 0.708
Kidneys	1.610 ± 0.147	1.745 ± 0.199	1.541 ± 0.133	1.459 ± 0.099	1.536 ± 0.218	1.615 ± 0.124
Adrenals	0.0666 ± 0.016	0.0747 ± 0.007	0.0676 ± 0.007	0.0628 ± 0.01	0.0608 ± 0.002	0.0712 ± 0.009
Ovaries	0.0956 ± 0.02	0.1077 ± 0.014	0.0942 ± 0.017	0.0956 ± 0.013	0.146 ± 0.043	0.1488 ± 0.029
Heart	0.764 ± 0.059	0.797 ± 0.039	0.750 ± 0.091	0.736 ± 0.079	0.828 ± 0.128	0.833 ± 0.089
Spleen	0.754 ± 0.163	0.802 ± 0.096	0.935 ± 0.195	0.725 ± 0.099	1.010 ± 0.063	0.868 ± 0.104
Lungs	1.307 ± 0.167	1.598 ± 0.428	1.514 ± 0.409	1.317 ± 0.168	1.007 ± 0.105	1.02 ± 0.149
Uterus	0.545 ± 0.155	0.549 ± 0.132	0.563 ± 0.167	0.492 ± 0.088	0.478 ± 0.119	0.522 ± 0.049