Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats

Table 1

Parameters for adult Fisher 344 rats and corresponding significance in the PBPK model. (Note: partition coefficients are unitless [8].)

Parameter		Significance	Value	Source
Miscellaneous	𝐵𝑊	Body weight	0.25 kg	[9]
	𝑄𝐶𝐶	Cardiac output	15 L/hr/kg^0.75	[10–12]
	loss	Chamber loss rate	0.025 (1/hr)	[9]
	𝑁	Number of rats	3	[9]
	𝑉cha	Chamber volume	9 (L)	[9]
Flow rates (L/hr)	𝑄𝑉	Ventilation/perfusion rate	1.7	[12]
	𝑞1	Rapidly perfused blood flow rate	𝑄𝑉−∑𝑞𝑖	∑𝑞𝑖 is the sum of other compartments
	𝑞2	Blood flow fraction to adipose	0.082	[11]
	𝑞3	Blood flow fraction to slowly perfused	0.257	Muscle+bone+skin values from [11]
	𝑞4	Blood flow fraction to kidney	0.138	[11]
	𝑞5	Blood flow fraction to liver	0.242	[11]
Partition coefficient	𝑃art	Blood/air	41.5	[9]
	𝑃liv	Liver/blood	0.7	[9]
	𝑃rap	Rapidly perfused/blood	0.7	Assumed to be same as liver
	𝑃kid	Kidney/blood	0.7	Assumed to be same as liver
	𝑃slow	Slowly perfused/blood	0.267	Muscle [9]
	𝑃adi	Adipose/blood	7.8	[9]
Volume (L)	𝑉slow	Volume fraction for slowly perfused	0.674	[11]
	𝑉liv	Volume fraction for liver	0.044	[11]
	𝑉kidney	Volume fraction for kidney	0.0075	[11]
	𝑉adi	Volume fraction for adipose	0.112	[11]
	𝑉rap	Rapidly perfused	0.91−∑𝑉𝑖	Total vol. — sum of all other
				compartments. Blood is 9% of BW