Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats

Table 2

Optimized parameter results.

Two-pathway model		Two-binding site model
𝑉max	3.8 mg/hour	𝑉max1	3.7 mg/hour
𝐾𝑚	0.35 mg/liter	𝐾𝑚1	0.3 mg/liter
𝑘GST	4.5/hour	CL2	0.047 liter/hour