Application of Purified Botulinum Type A Neurotoxin to Treat Experimental Trigeminal Neuropathy in Rats and Patients with Urinary Incontinence and Prostatic Hyperplasia

Figure 3

Mechanical allodynia after injection with type A NTX or PTXs in a rat hindpaw neuropathy model. Mechanical allodynia was tested with an electric von Frey filament and the hindpaw withdrawal thresholds measured. The data were divided by the contralateral naïve hindpaw data. After sciatic nerve contraction, the ipsilateral hindpaw threshold was decreased. Ipsilateral injection with NTX or HA-positive PTXs produced the same toxicity (10 U/0.1 mL) in mechanical allodynia. The effects of NTX on decreasing pain levels were longer lasting than HA-positive PTXs. 𝑛=4; data represent the mean ± SEM.