Research Article
Reconstruction of Exposure to m-Xylene from Human Biomonitoring Data Using PBPK Modelling, Bayesian Inference, and Markov Chain Monte Carlo Simulation
Table 1
Individual volunteer parameters.
| Volunteer | Age | Body weight (BW) (kg) | Height (m) | BMI (kg/m2) | Mass of body fat (VfaC) (% (BW)) | Resting alveolar ventilation rate (QPC) (l/hr) | Urine flow (Rurine) (l/hr) | Urinary creatinine (CRE) (mmol/l) | m-Xylene blood : air partition coefficient (Pba) |
| A | 54 | 79 | 1.68 | 28.00 | 0.218 | 383.3 | 0.070 | 14.8 | 15.1 | B | 51 | 61.5 | 1.78 | 19.32 | 0.192 | 409.3 | 0.125 | 7.30 | 16.8 | C | 47 | 89 | 1.91 | 24.40 | 0.169 | 477.5 | 0.090 | 14.9 | 11.4 | D | 48 | 85 | 1.75 | 27.80 | 0.263 | 362.7 | 0.091 | 13.0 | 18.0 | E | 29 | 76 | 1.85 | 22.20 | 0.130 | 327.2 | 0.088 | 12.5 | 26.5 | F | 25 | 76 | 1.83 | 22.70 | 0.162 | 352.6 | 0.055 | 14.8 | 20.2 | G | 41 | 75 | 1.70 | 26.00 | 0.179 | 462.2 | 0.076 | 12.8 | — | H | 29 | 68 | 1.70 | 23.50 | 0.299 | 348.6 | 0.074 | 10.2 | 21.6 | Mean | | 76.2 | 1.78 | 24.24 | 0.202 | 390.4 | 0.083 | 12.5 | 18.5 | SD | | 8.73 | 0.08 | 2.95 | 0.056 | 54.89 | 0.021 | 2.70 | 4.90 | CV | | 0.115 | 0.05 | 0.122 | 0.277 | 0.141 | 0.247 | 0.212 | 0.26 |
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