Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II: Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment
Figure 6
Distributions (min, 5th, med, 95th and max) of globus pallidus concentrations simulated for a human population with the input distributions described in Scenario 3 (see text for more details). Comparison of steady-state brain manganese concentration following 365 days of continuous exposure (24 hr/7 days). There is an overlap of tissue Mn levels between inhaled exposure and dietary variability. Changes in globus pallidal manganese concentrations from exposures <0.05 mg Mn/m3 are small when compared to the impact of normal dietary variation.
