Develop the basic structure of a multiroute PBPK model for Mn.
Blood, brain, respiratory tract (nasal and lung), liver, kidneys, bone, and muscle (rest of body) compartments consisting of a “shallow” tissue pool in rapid equilibration with blood and a “deep” tissue store, connected to the shallow pool by transfer rate constants .
54Mn: IP, INH Rodent
Rodent tracer studies describing 54Mn distribution to various tissues and 54Mn elimination kinetics.
Develop a multiroute Mn PBPK model for adult rats.
Same compartments as above . Model A used simple rate constants  to describe inter-compartmental movement of Mn. Model B had tissue binding kinetics described by dissociation and association constants ( and ), and maximum concentration of binding capacity ().
Mn: O, INH 54Mn: IV Rat
Rats fed on diets containing 2 to 100 ppm Mn, Rats fed a diet containing 125 ppm Mn and exposed via inhalation at 0.0 to 3.00 mg Mn/m3 each day for 14 d. Rats exposed to 0.1 or 0.5 mg Mn/m3 for 6 h/d, 5 d/wk over a 90-day period.