Research Article
Bayesian Analysis of a Lipid-Based Physiologically Based Toxicokinetic Model for a Mixture of PCBs in Rats
Table 2
Physiological values for a standard 225 g rat (adapted from [
11]).
| Tissue | Conventional model† | NLE-based model |
| Blood flow rates |
| Fat | 448 mL/h | 0.85 mL lipid/h | Liver | 1245 mL/h | 2.36 mL lipid/h | Rapidly perfused | 2540 mL/h | 4.82 mL lipid/h | Poorly perfused | 747 mL/h | 1.42 mL lipid/h | Cardiac output | 4980 mL/h | 9.45 mL lipid/h |
| Volumes |
| Blood | 20.0 mL | 0.038 mL lipid | Fat | 17.5 mL | 14.938 mL lipid | Liver | 10.0 mL | 0.425 mL lipid | Rapidly perfused | 12.5 mL | 0.531 mL lipid | Poorly perfused | 167.5 mL | 2.010 mL lipid |
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†Physiological parameter values obtained from [15, 16].
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