Research Article

Bayesian Analysis of a Lipid-Based Physiologically Based Toxicokinetic Model for a Mixture of PCBs in Rats

Table 2

Physiological values for a standard 225 g rat (adapted from [11]).

TissueConventional modelNLE-based model

Blood flow rates

Fat448 mL/h0.85 mL lipid/h
Liver1245 mL/h2.36 mL lipid/h
Rapidly perfused2540 mL/h4.82 mL lipid/h
Poorly perfused747 mL/h1.42 mL lipid/h
Cardiac output4980 mL/h9.45 mL lipid/h

Volumes

Blood20.0 mL0.038 mL lipid
Fat17.5 mL14.938 mL lipid
Liver10.0 mL0.425 mL lipid
Rapidly perfused12.5 mL0.531 mL lipid
Poorly perfused167.5 mL2.010 mL lipid

Physiological parameter values obtained from [15, 16].