Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment

<table>A schematic diagram of the physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model of acetylcholinesterase (AchE) inhibition by binary mixtures of chlorpyrifos, parathion, and their metabolites: chlorpyrifos-oxon and paraoxon.</table>

Journal of Toxicology

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Figure 2

Figure 2: Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment 