Table 1: Model parameters for the ethanol PBPK.

Physiological parameters of the model PBPK for ethanol

 Body weight70
 Cardiac output (L/h/kg)0.7518
 Alveolar ventilation (L/h/kg)0.7518
 Absorbed fraction0.62

Fraction of cardiac output to each compartment

 Fat0.05
 Liver0.25
 Rapidly perfused0.39
 Slowly perfused0.19
 Brain0.12

 Total1.00

Fraction of body volume compartments

 Fat0.213
 Liver0.0257
 Rapidly perfused0.0443
 Slowly perfused0.607
 Brain0.02

 Total0.91

Physicochemical and metabolic parameters

Partition coefficients
 Blood: air2280
 Fat: air226
 Liver: air1730
 Rapidly perfused: air2030
 Slowly perfused: air1710
 Brain: air1870

Liver metabolic parameter

 Metabolism rate (mg/h/kg)0.75359.5
 Affinity constant (mg/L)82.1