Use of Clostridium perfringens Enterotoxin and the Enterotoxin Receptor-Binding Domain (C-CPE) for Cancer Treatment: Opportunities and Challenges
Figure 3
Efficacy of CPE in the treatment of breast cancer brain metastasis. (a, b) Brain tumors were established in mice using the human breast cancer cell line MDA-MB-468 and the murine breast cancer cell line NT2.5-luc. Tumors were treated by intracranial administration of 0.5 μg CPE versus PBS on days 5, 7, and 9. (c, d) For the NT2.5-luc brain tumor model, noninvasive bioluminescent imaging was done twice per week beginning on day 4. Bioluminescent images from five representative mice are shown for each experimental group at day 19 (c). Photon flux was measured over the indicated time course as an indication of tumor growth (d). Differences in survival between experimental groups were analyzed using the log-rank test. Reproduced with permission from [20].
