Use of Clostridium perfringens Enterotoxin and the Enterotoxin Receptor-Binding Domain (C-CPE) for Cancer Treatment: Opportunities and Challenges

Figure 4

Combination therapy of C-CPE and taxol attenuates EOC xenograft growth in vivo. Female SCID mice were inoculated s.c. with 5×10⁶ SKOV-3 cells. Four weeks later, the mice harboring large tumor burden were intraperitoneally administered with taxol alone (20 mg/kg), taxol combined with C-CPE (0.1 mg/kg), or vehicle (PBS) twice a week for 4 weeks. (a) Growth curves of tumors were presented as the mean volume normalized to the start volume. *The combination of C-CPE and taxol led to a significant tumor suppression compared with vehicle or taxol alone (𝑃<0.05). (b) After 4 weeks of treatment, immunostaining of Ki67 and TUNEL was performed to evaluate cell proliferation and apoptosis in EOC xenografts. ^∗𝑃<0.05; ^∗∗𝑃<0.001. Reproduced with permission from [35].