Clinical Validation of a Highly Sensitive GC-MS Platform for Routine Urine Drug Screening and Real-Time Reporting of up to 212 Drugs

Figure 1

Lowest concentration of each of the 212 drugs detected by the new GC-MS platform. Dilutions of urine containing spikes of drug standards prepared by spiking 1, 10, 100, and 1000 ng/mL into negative urine were used to determine the analytical sensitivity of the platform. If the drug could not be detected at the lowest concentration tested, the next higher concentration of the drug was analyzed. Analytical sensitivity of the drug was recorded as the lowest formulated concentration at which the drug was detected (see Supplementary Material available online at http://dx.doi.org/10.1155/2013/329407 for the list of all drugs along with the lowest concentrations at which each drug was detected).