Clinical Validation of a Highly Sensitive GC-MS Platform for Routine Urine Drug Screening and Real-Time Reporting of up to 212 Drugs

Figure 4

Comparison of the number of drugs identified by the new, reference, and mixed configuration platforms. The number of drugs reported per patient is shown against each configuration, and the statistical significance (𝑃 value) in the differences in the number of drugs reported for three configurations compared is provided. Statistically valid (𝑃 value = 0.0038) increment in the number of drugs was reported when the data from the reference GC-MS instrument is analyzed using AMDIS in conjunction with the new in-house library compared to the use of the default data analysis approach. In-addition, both data generated using the reference instrument and that by the new platform were analyzed using AMDIS in conjunction with the new in-house library. The results from this comparison show that an even higher and statistically significant (𝑃 value = 0.0029) increment in the number of drugs was reported from the data generated by the new platform compared to the data generated by the reference platform.