A Systematic Review of Carcinogenic Outcomes and Potential Mechanisms from Exposure to 2,4-D and MCPA in the Environment

Table 11

Oral equivalent doses based on ToxCast dosimetry and estimated urinary levels associated with oral doses.

2,4-D	BW (kg)	24 hr urine volume (L)	In vitro-in vivo equivalent dose (mg/kg-d)	Scenario	Estimated urine level from oral dose (μg/L)
Children 4–12	30	0.66	0.014	Lowest biologically relevant ToxCast assay result; highest predicted 𝐶ss	636
Adolescents	55	1.7	0.014		453
Women	55	1.6	0.014		481
Men	70	1.7	0.014		576
Children 4–12	30	0.66	0.028	Lowest biologically relevant ToxCast assay result; average predicted 𝐶ss	1273
Adolescents	55	1.7	0.028		906
Women	55	1.6	0.028		963
Men	70	1.7	0.028		1153
MCPA
Children 4–12	30	0.66	0.01	Lowest biologically relevant ToxCast assay result; highest predicted 𝐶ss	455
Adolescents	55	1.7	0.01		324
Women	55	1.6	0.01		344
Men	70	1.7	0.01		412
Children 4–12	30	0.66	0.0005	Oral RfD	23
Adolescents	55	1.7	0.0005		16
Women	55	1.6	0.0005		17
Men	70	1.7	0.0005		21
Children 4–12	30	0.66	0.0044	Oral RfD used by Health Canada; OPPTS	200
Adolescents	55	1.7	0.0044		142
Women	55	1.6	0.0044		151
Men	70	1.7	0.0044		181