Journal of Toxicology / 2013 / Article / Tab 4 / Review Article
A Systematic Review of Carcinogenic Outcomes and Potential Mechanisms from Exposure to 2,4-D and MCPA in the Environment Table 4 Epidemiologic studies by histological subtype for NHL.
Type of lymphoma Number exposed Chlorophenoxys MCPA 2,4-D and/or 2,4,5-T Reference B-cell lymphomas total 819 1.99 (1.2–2.32) 2.59 (1.14–5.91) 1.69 (0.94–3.01) Eriksson et al. [71 ] 665 1.47 (0.33–6.64) Fritschi et al. [67 ] Lymphocytic 196 2.11 (0.99–4.47) 2.57 (0.74–8.97) 1.93 (0.85–4.41) Eriksson et al. [71 ] Follicular 165 1.26 (0.42–3.75) — 1.21 (0.35–4.22) Eriksson et al. [71 ] 227 1.15 (0.12–11.2) Fritschi et al.[67 ] 27 0.8 (0.2–3.6) Orsi et al. [70 ] Diffuse large B cell 239 2.6 (1.08–4.33) 3.94 (1.48–10.5) 1.65 (0.71–3.82) Eriksson et al. [71 ] 231 2.16 (0.36–13.1) Fritschi et al. [67 ] 30 1.0 (0.4–2.8) Orsi et al. [70 ] Other specified B cell 131 2.60 (1.20–5.64) 3.2 (0.95–10.7) 2.21 (0.9–5.44) Eriksson et al. [71 ] Unspecified B cell 89 1.14 (0.33–3.95) 1.35 (0.16–11.2) 0.88 (0.2–3.92) Eriksson et al. [71 ] T cell 53 1.62 (0.36–7.25) 2.4 (0.29–20) 1.02 (0.13–7.95) Eriksson et al. [71 ] Unspecified NHL 38 3.75 (1.16–12.1) 9.31 (2.11–41.2) 3.21 (0.85–12.1) Eriksson et al. [71 ]
Hoar et al. [57 ] reported no differences in the ORs associated with herbicide use when cases were categorized by histological subtype (specific results not reported). Hardell et al. [56 ] reported no differences in the ORs associated with herbicide use when cases were categorized by histological subtype (specific results not reported).