Influence of Exposure to Benzo[a]pyrene on Mice Testicular Germ Cells during Spermatogenesis
Figure 2
Cross section of seminiferous tubules of adult mice exposed to B[a]P at 50 mg/kg/day and 100 mg/kg/day for 30 days and the control. (a) Control, 100x showing seminiferous tubule integrity, organized seminiferous epithelium, normal luminal space, and numbers of maturing spermatozoa, (b) 50 mg/kg/day, 100x, seminiferous tubule integrity beginning to decline, seminiferous epithelium although still highly organized, showing a loss of integrity among the Sertoli cells, and (c) 100 mg/kg/day, reduced width of adluminal compartment of the seminiferous tubules, lost integrity of cellular membranes, the atrophy of seminiferous tubules, lack of spermatids and spermatozoa, and altered morphology of spermatogonia and spermatocytes.
