Effect of the Antibiotic Neomycin on the Toxicity of the Glycoside Vicine in Rats

Table 5

Effect of vicine and neomycin on serum and liver transaminases (ALT and AST) in rats.

Parameters	Group
	Control; (1 mL saline)	Vicine; (400 mg/kg)	Neomycin (250 mg/kg); + Vicine (400 mg/kg)
Serum AST (U/L)	17.51±3.95	3.21±1.23^∗∗∗	15.31±3.51^b
Serum ALT (U/L)	8.54±3.2	5.86±1.23^∗	8.21±2.23^a
Liver AST (U/g tissue)	48.25±6.22	91.54±3.23^∗∗∗	55.12±4.5^b
Liver ALT (U/g tissue)	35.41±4.35	64.22±7.51^∗∗	37.44±6.25^b

Results were expressed as mean±SD and significant difference according to control group at 𝑃≤0.05, ANOVA showed a highly significant difference between all groups at 𝑃≤0.0001.^∗𝑃≤0.05 significant difference compared to control. ^∗∗𝑃≤0.01 highly significant difference compared to control. ***Very highly significant at 𝑃≤0.001 compared to control ^a𝑃≤0.05 significant difference compared to vicine. ^b𝑃≤0.01 highly significant difference compared to vicine.