Table 1: Cell survival IC50 (half maximal inhibitory concentration) values of dog and rat hepatocytes treated with phospholipogenic or nonphospholipogenic compounds. Cells were fixed with formaldehyde/Hoescht, and survival was quantified using the Cellomics Arrayscan instrument (see Materials and Methods). Isolates were obtained on different days. The data are represented as individual experiments only ( = 1 or 2) or as an average of 3 individual (separate isolates, = 3) experiments ± SD.

DogRat
Survival IC50μMSurvival IC50μM

Phospholipogenic compounds

NMTMB37 ± 13a148 ± 41
A298 ± 22 >450 (3)
B153 ± 63>300 (3)
Hydroxychloroquine90, 159220, >300
Fluoxetine1961

Nonphospholipogenic compounds

Diclofenac656832
C>300>300
D>300>300

Statistically significant (P < 0.05, t-test) differences observed in species’ response.