Review Article
Scorpion Peptides: Potential Use for New Drug Development
Table 1
List of various families of polypeptides isolated from scorpion venom and hemolymph.
| Family | Subfamilies | Targeted site |
| Peptides acting on Na+ channels |
| | -Mammals (classic) | | -NaTxs [23] | -Like | Site 3 | | -Insect | | | -Mammals | | -NaTxs [23] | -Insect (depressant) | Site 4 | | -Insect (contracturant)
| |
| Peptides acting on K+ channels |
| -KTXs [23] | In conjunction with the appropriate targeted site. | Kv1.x channels | KCa1.1 | KCa2.x | KCa3.1 | Kv11.x | -KTXs [23] | Nd | Nd | -KTXs [23] | Nd | Kv11.x | -hefutoxin [23] | Nd | Kv1.x |
| Peptides acting on Cl− channels |
| Nd [23] | Nd |
Ca2+-activated Cl− channels (CFTR) |
| Peptides acting on Ca2+ channels |
| Nd [31–35] | Nd | Ryanodine receptor |
| Peptides with free cysteine residues |
| BPPs [10] | Nd | Nd | AMPs [26] | Nd | Membrane phospholipids |
| Peptides with enzymatic activities |
| PLAs2 [27] | Nd | Nd | Hyaluronidases [30] | Nd | Nd |
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