Botulinum Toxin Suppression of CNS Network Activity In Vitro

Table 1

Antisera protection experiments.

Experiment	Tissue type	Age (d.i.v.)	SERUM		Delay	BoNT-A (ng/mL)	Protection; Yes/No	Experiment duration (h)
			#	Conc.
BT-016	SC	86	76	0.3%	0.3 h	100	No	18
BT-017	FC	28	32	1.0%	1.1 h	100	No	8
BT-019	FC	52	83	5%	0.4 h	100	Yes	19
BT-068	FC	33	4	5%	20 h	50	Yes	50
BT-070	FC	40	4	1.3%	3.0 h	50	Yes	15
BT-072	SC	29	4	0.5%	1.2 h	50	No	21
BT-074	SC	36	4	1%	4.2 h	50	No	18.3
BT-075	SC	37	23	1%	2.3 h	50	No	16.8
BT-076	FC	39	23	2%	0.7 h	50	Yes	20
BT-077a	FC	40	23	2%	0.3 h	50	Yes	15.2
BT-077b	Continuation					100	Yes
BT-077c	Continuation					150	Yes
BT-077d	Continuation					200	Yes	45

FC: frontal cortex; SC: spinal cord.
Delay: time between serum addition and BoNT-A addition.