Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats

Table 1

Acute oral toxicity record sheet for control and extract treated animals (𝑛=6).

Additional observations

Drug P.O

Toxicity

Time of death

ANS/CNS

Behavioural observations

onset

Stop

Skin and fur

Eye lacri

Sali

Diah

Resp

Leth

Sleep

Con

Coma

Ste

Tre

Cat

Geo

Hal

Retr

Stu

Exe

CON

nil

Nil

0

×

×

×

×

×

×

×

×

×

×

×

×

×

×

×

×

×

ALA

nil

Nil

0

×

×

×

×

×

×

×

×

×

×

×

×

×

×

×

×

×

ABA

nil

Nil

0

×

×

×

×

×

×

×

×

×

×

×

×

×

×

×

×

×

ALM

nil

Nil

0

×

×

×

×

×

×

×

×

×

×

×

×

×

×

×

×

×

ABM

nil

Nil

0

×

×

×

×

×

×

×

×

×

×

×

×

×

×

×

×

×

Con: control; ALA: leaf aqueous extract; ALM: leaf 80% MEOH extract; ABA: bark aqueous extract; ABM: bark 80% MEOH extract.
Lacri: lacrimination, Sali: salivation, Diah: diarrhoea, Resp: respiratory distress, Leth: lethargy, Con: convulsions, Ste: stereotypy, Tre: tremors, Cat: catalepsy, Geo: effect on positive geotropism, Ret: retropulsion, Stu: stupor, Exe: excitement, ×: absence of symptom, ✓: presence of symptom.