Neuroprotective Effects of Alpha-Mangostin on MPP⁺-Induced Apoptotic Cell Death in Neuroblastoma SH-SY5Y Cells

Figure 6

Effect of alpha-mangostin on the MPP⁺-induced ROS production in SH-SY5Y cells. Intracellular ROS production was measured after treatment cells with 10 μM alpha-mangostin (α-M), 1000 μM MPP⁺, or the combination of α-M and MPP⁺ for 6 hours. Flow cytometric analysis of ROS production is presented as the mean fluorescence intensity (MFI), as assessed by incubation with DHE (a) and DHR123 fluorescence dye (b). Data are expressed as mean ± SEM (), compared to untreated cells. .

(a)

(b)