Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats

Table 1

Comparison between effects of cyclosporine different doses on the rats’ lung weight, body weight, and the lung/body weight ratio.

Parameter	Group
	First	Second	Third
	M ± SD	M ± SD	M ± SD
Body weight (gm)	210.9 ± 15.11	155.35 ± 12.15	99.55 ± 10.26
Lung weight (gm)	2.4 ± 0.18	1.9 ± 0.19	1.3 ± 0.24
Lung/body weight ratio %	1.14	1.22	1.31

First group: physiological saline (control).
Second group: cyclosporine (25 mg/kg/day).
Third group: cyclosporine (40 mg/kg/day).
M ± SD: mean ± standard deviation. Number per group: 20
⁢: significant difference in comparison with the control group
⁢: significant difference in comparison with the second group.